The earliest signal is injection site behavior
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In prostate cancer cells, phenethyl isothiocyanate, a phytochemical found in large amounts in cruciferous vegetables, was reported to restore expression of silenced GSTP1 by a mechanism involving promoter demethylation and increased histone acetylation
TrumpRx, a federal purchasing portal announced November 2025 and launching January 2026, uses the threat of 100% tariffs on pharmaceutical imports to force Novo Nordisk, Eli Lilly, and other manufacturers into Most Favored Nation pricing agreements that bring GLP-1 injectables down to ~$350/month for cash-pay users, bypassing the insurance, PBM, and traditional pharmacies & competing directly with Ro by redirecting patients who search for drugs on TrumpRx.gov to the same manufacturer cash-pay pharmacies Ro pipes into
Wegovy can sit at room temperature (59F86F) for up to 28 days before its first use
Wegovy, the weightlossspecific formulation, entered the market in 2025