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This erosion directly exposes colonic epithelium to luminal cytotoxic compounds and enteric pathogensincluding bacterial lipopolysaccharides (LPS) (Ijssennagger et al., 2015)

It binds poorly to IGF-binding proteins, which normally sequester IGF-1 in the body, allowing it to remain active and available for a significantly longer period

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For a patient in this study, maintenance of response, along with reductions in lesion-associated symptoms and in redness, thickness, and scale, scored the highest when rating importance of a drug

Second, standardized safety evaluation frameworks including long-term biodistribution, immunogenicity, and clearance studies should be aligned with FDA/EMA guidelines to reduce regulatory uncertainty