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GLP-1 neuronal circuits in hypothalamic appetite regulation and food reward processing Metabolic surgery pharmacology : Studying whether pharmacological dual incretin agonism can replicate the hormonal changes and metabolic benefits of bariatric surgery Cardiovascular research : Elucidating mechanisms of cardiovascular risk reduction via combined GIP/GLP-1 receptor activation NASH/MAFLD research : Exploring effects on hepatic steatosis, inflammation, and fibrosis (SYNERGY-NASH trial ongoing) Peptide engineering : Studying multi-target receptor agonism as a design paradigm how to engineer selectivity ratios across receptor families Comparative pharmacology : Benchmarking dual (GIP/GLP-1) vs

10.1016/j.curtheres.2014.01.001 58 Tuba-KartalA.ala-MutluZ