Hayashi, Daisuke, et al
[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Nadkarni P, Chepurny OG, Holz GG
For example, the STEP 1 trial of once-weekly semaglutide (2.4 mg) in people without diabetes achieved a ~15% average body weight reduction over 68 weeks (source), with a mean baseline BMI of ~38 (source)
Other Considerations: When choosing a GLP-1 analogue for weight management, factors such as medication cost, insurance coverage, and personal preferences may come into play
16 GLP-1 receptors are found in key brain regions that handle cognition and energy metabolism, including the neocortex, hippocampus, and hypothalamus
In recent years, GLP-1R and its agonists have become a hot research topic and a star drug in the field of diabetes treatment