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(2025) Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment (ATTAIN-1)

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If additional glycaemic control is needed after at least 4 weeks, the dose may be increased to 1 mg once weekly and potentially to 2 mg once weekly if required and tolerated

The -propeller domain packs against the / hydrolase domain, and the catalytic triad (residues Ser630, His740 and Asp708) is located at the interface between the two domains (Aertgeerts et al., 2004)

Some practices still refer more complex cases on to a specialist