Once-weekly semaglutide in adults with overweight or obesity
Invert the vial so the needle points upward
An enzyme called dipeptidyl peptidase-4 (DPP-4) cleaves and inactivates GLP-1 almost instantly, preventing it from reaching therapeutic targets in any meaningful way
And for many, they delivered: 10%, 15%, or even 20% body weight lost Lower glucose, blood pressure, and inflammation Fewer heart attacks, as seen in the SELECT trial It felt like medicine had cracked the metabolic code
2 The three main tasks of natural GLP-1: In the brain: it acts as a fullness switch, telling your brain that you have had enough to eat, which naturally reduces your appetite and interest in food
However, the role of GLP-1 RAs in psychiatric outcomes, particularly in depression or anxiety disorder, presents a mixed picture