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By 2024, research expanded the cardio-renal framework to include hepatic dysfunction, recognizing its role in metabolic disturbances disturbances ( In February 2025, Theodorakis and Nikolaou proposed an expanded framework transitioning from CKM to CRHM syndrome ( 3 Pathophysiology of cardio-renal-hepatic-metabolic syndrome The pathophysiology of CRHM syndrome is driven by a multifaceted interaction of unified mechanisms, creating a self-perpetuating cycle of multi-organ dysfunction

Glutathione's primary role is protecting cells from oxidative stress, which is one of the leading causes of premature graying

Programmed cell death in plants: a pathogen-triggered response activated coordinately with multiple defense functions

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PCOS, perimenopause, menopause, stress, sleep deprivation, and metabolic changes can all affect weight