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Inhibition oF DPP-4 activity and bone metabolism Some studies have shown that greater DPP-4 levels or activity correlate with decreased BMD as well as increased bone resorption markers, risk of fractures, and inflammatory markers ( e.g

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In addition, there was a modest statistically significant association for stroke/TIA and a suggestive, non-significant trend for MI, while coronary revascularization and hospitalization were not significantly reduced