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A phase Ib clinical trial NCT03528642 examined CB-839/telaglenastat safety and anti-tumor activity in combination with radiation therapy and temozolomide in patients with IDH-mutated diffuse or anaplastic astrocytoma

doi: 10.1038/ni1276 4 BaechleJJChenNMakhijaniPWinerSFurmanDWinerDA

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In addition, inhibiting METTL17 significantly reduces mitochondrial RNA methylation, impairing the translation of mitochondrial protein-coding genes, affecting mitochondrial energy metabolism, and enhancing mitochondrial and intracellular ROS and lipid peroxidation levels

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The tripeptide has a molecular weight of roughly 340 Da, placing it below the 500 Da heuristic cutoff for passive skin penetration