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Emerging evidence highlights a range of contributing factors, including reduced mechanical loading, increased bone marrow adiposity, hormonal and endocrine alterations, nutritional deficiencies, and disruptions in energy metabolism

Association and interaction of the MC4R rs17782313 polymorphism with plasma ghrelin, GLP-1, cortisol, food intake and eating behaviors

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The interaction with these proteins highlights its participation in a coordinated defense mechanism against chemical insults