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Tirzepatide, sold as Zepbound for weight management, activates GLP-1 receptors along with receptors for glucose-dependent insulinotropic polypeptide, or GIP, another hormone involved in appetite and blood-sugar regulation
PubMed, Maselli, Daniel, et al
Since their debut, these novel agents have formed an important armamentarium in the management of T2DM
It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat
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Many food companies have already been feeling the heat, as consumers shun sugar, fat and calories for protein and fibre
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