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Meier J, Gallwitz B, Siepmann N, Holst JJ, Deacon CF, Schmidt W, et al

Final Thoughts While GLP-1 medications offer a helpful tool for some, they simply cant match the weight loss or health benefits of bariatric surgery

Renal function should be monitored, as severe gastrointestinal adverse effects can lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment

Patients with Chronic Pulmonary Disease: Hydrocodone bitartrate and acetaminophen tablet-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of hydrocodone bitartrate and acetaminophen tablets (see WARNINGS, Life-Threatening Respiratory Depression)

Clinically, this synergy is relevant in immune dysfunction, chronic fatigue, skin aging, cardiovascular risk, and metabolic stress