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The Bottom Line GLP-1 medications affect iron absorption through three interconnected mechanisms: delayed gastric emptying reduces the time iron spends in optimal absorption zones, appetite suppression decreases total iron intake, and metabolic changes may alter how your body stores and utilizes iron after absorption

In the STEP 1 trial extension, participants regained roughly two-thirds of their lost weight in the year after stopping semaglutide, with cardiometabolic improvements largely reverting toward baseline

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It is important to follow your prescribing doctors instructions carefully when stopping semaglutide before an endoscopy or any sedated medical procedure