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For women with lipoedema who already commonly present with digestive issues, histamine intolerance, MCAS, reflux associated with hiatus hernia, or who wear compression garments that fit around the abdomen, which can place upward pressure on the stomach, this cascade of gastrointestinal complications is a very real and underacknowledged risk that needs consideration before starting these medications

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Doses around 2,000 mg per day showed the maximum benefit

However, when these systems falter, the consequences are profound: misfolded proteins accumulate, aberrant antigen presentation fuels immune hyperactivation, and chronic inflammation spirals out of control