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However, the lightening effects are temporary, once you stop, melanin production resumes, and your skin gradually returns to its original color over several weeks to months

While numerous proof-of-concept candidate molecules have been disclosed (43), the only approved example of multi-receptor agonism for obesity and T2D is the dual GLP-1R/GIPR co-agonist tirzepatide (marketed as Mounjaro and Zepbound ) (44)

"They quiet the chronic inflammation that comes with carrying extra weight," he adds

one patient had an initial improvement in both glycemia and weight followed by weight regain and deterioration of glycaemic control, and one patient experienced only glycemia improvement with weight gain (42)

To learn whether a medically guided weight-loss program may be appropriate for your goals, contact Dr