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The playbook was category expansion powered by a single nutritional premise: whole grains plus protein
It has been postulated that a defect of fatty acid synthesis due to reduced activity of acetyl CoA carboxylase is implicated in the skin manifestations of MCD and biotin deficiency (5)
Quantification was performed using internal standards and calibration curves to ensure accuracy
Baseline laboratory evaluation should include a complete blood count with differential, comprehensive metabolic panel, hepatic function tests, and tumor markers selected according to the patients demographics, family history, and clinical context
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