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without eating or drinking anything except water for 8 - 12 hours beforehand

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1b) and carnitine palmitoyltransferase 1 (CPT1) (ESM Fig

These challenges highlight why combining lifestyle changes with other methods might be more effective for some individuals

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The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository (proteomexchange.org) with the data set identifier PXD036803 ( The mass spectrometry metabolomics data (2 data sets from kidney and plasma, respectively) have been deposited to the Zenodo repository ( All reagents, softwares, mouse lines, and data repository information are available in Supplemental Table 7