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The second step in glutathione (GSH) synthesis is catalyzed by the enzyme Glutathione Synthase (GS, EC 6.3.2.3, formerly known as GSH synthetase)

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For example, cis-3-(9H-purin-6-ylthio)acrylic acid (PTA) is a prodrug of the antitumor and immunosuppressive antimetabolite 6-mercaptopurine that requires GSH conjugation and subsequent metabolism for activation (Gunnarsdottir and Elfarra, 1999)

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Bone (2015) 81:45967.10.1016/j.bone.2015.08.006 31 IepsenEWLundgrenJRHartmannBPedersenOHansenTJorgensenNRet alGLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women