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Those with symptomatic heart failure need individualized evaluation, though these medications are not absolutely contraindicated in most cardiac conditions

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However, a PubMed systematic literature review found the incidence of thyroid cancer associated with semaglutide use to be less than 1% (36)

Therefore, because neurotransmitter imbalance contributes to depressive behaviors in patients with depression as described above, the appropriate modulation of neurotransmitters in the brain is key to treating depression ( Figure 2 )