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Similar patterns have been found in oral cancer and in patients receiving immunotherapy, where elevated B12 has been associated with poorer outcomes

Intranasal GSH has shown potential to raise brain GSH levels (Aoyama & Nakaki, 2021)

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Murphy and George R

Further, targeted metabolomics results revealed that GGCT knockdown markedly attenuated TCA cycle flux, decreasing key intermediates including pyruvate, succinate and fumarate (Fig