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Another study presented in July 2025 at ENDO 2025, the Endocrine Societys annual meeting, found that a combination of HRT and the hormone therapy helped women maintain a healthy weight

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84 During the oxidative folding process of endoplasmic reticulum (ER) proteins, the formation of disulfide bonds produces the byproduct H 2 O 2 , which is released into the nucleus to modulate the level of the aging-related gene SERPINE1 and promote cell senescence

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