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Investigations are guided by clinical suspicion rather than routine panels: for example, thyroid function tests and ferritin may be checked if symptoms suggest deficiency or thyroid disease, while an androgen profile may be appropriate in women presenting with menstrual irregularity, hirsutism, or acne

doi: 10.1016/j.biopha.2017.08.009

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Endogenously, this occurs 612 times per day, with the largest pulses during slow-wave sleep

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