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Group III (10 patients) received oral placebo capsules (as a control) once daily for 4 weeks

The esophagus is not designed to handle the high acidity of stomach juices

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Studies using rat pinealocytes demonstrated that Epithalon upregulates both arylalkylamine N-acetyltransferase (AANAT) and phosphorylated CREB (pCREB), the rate-limiting enzymes in melatonin synthesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Hakeshzadeh F., Tabibi H., Ahmadinejad M., Malakoutian T., Hedayati M