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In spite of the substantially reduced coupling to G s , exendinphe1 acts as a full agonist for acute cAMP production in pancreatic beta cells as well as heterologous cell lines (Jones, Bloom, et al., 2018), presumably due to the availability of spare receptors and signal amplification

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doi: 10.3389/fnut.2022.983450 Received 01 July 2022 Accepted 27 July 2022 Published 17 August 2022 Volume 9 - 2022 Edited by Er Sheng Gong, Gannan Medical University, China Reviewed by Jiunn-Wang Liao, National Chung Hsing University, Taiwan

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