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Our evidences suggested that impaired mitophagy may be a cause of cardiac hypertrophy induced by pressure overload, and semaglutide ameliorated the cardiac hypertrophy by improving mitophagy to suppress the activation of NLRP3 inflammasome (Fig

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When combined with lifestyle modifications like regular exercise and reduced sodium intake, semaglutide's weight loss effects may allow some patients to reduce the number of blood pressure medications they take