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[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Sato K

From a biochemical standpoint, pushing the balance too far toward NADH relative to NAD plus can disrupt redox balance, which helps explain why overly aggressive dosing or stacking multiple NAD approaches may increase side effects rather than benefits

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In addition, BH4 enhances the biosynthesis of CoQ10 by influencing the synthesis of its precursor, 4-OH-benzoate