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This approach is aimed at smoothing out the medications effects, potentially reducing the intensity of side effects, and allowing the body to adapt more gently

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Interestingly, TFAM and mtDNA form a self-regulatory positive feedback loop: TFAM knockout triggers mtDNA depletion, while reduced mtDNA copy numbers further promote TFAM degradation [54,55,56] (Table 1)

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Mild nausea or bloating Occasionally reported when dosing begins but often subsides after a few days

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