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Retatrutide may negatively interact with the following cardiovascular and anti-diabetic medications: Warfarin (Coumadin) Losartan (Cozaar) Valsartan (Diovan) Eprosartan (Teveten) Azilsartan (Edarbi) Candesartan (Atacand) Irbesartan (Avapro) Telmisartan (Micardis) Metoprolol (Lopressor) Atenolol (Tenormin) Propranolol (AY-20694) Captopril (Capoten) Enalapril (Renitec) Lisinopril (Prinivil) Benazepril (Lotensin) Fosinopril (Monopril) Quinapril (Accupril) Ramipril (Altace) Perindopril (Coversum) Moexipril (Univasc) Trandolapril (Mavik) Insulin (Novolin) Glipizide (Glucotrol) Glibenclamide (Glynase) Gliclazide (Diaprel) Does Retatrutide Pose Any Risks to Health
Last reviewed: June 16, 2026 Last updated: June 16, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Prospective Studies Collaboration, Whitlock G, Lewington S, et al
The other authors declare no competing interests
Meta-analyses of berberine trials show modest reductions in hemoglobin A1c (approximately 0.5-0.7%) and fasting glucose, with variable effects on body weight, though many studies have methodological limitations and high heterogeneity
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