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Lixisenatide is a daily GLP-1RA developed by Zealand Pharma, which prolongs its half-life through structure-inducing probe technology based on exendin-4/exenatide

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The negation program is designed to lower the cost of drugs available through Medicare Part B

Other research highlights: 30% of GLP-1 users tested positive for SIBO or IMO even after accounting for diabetes (5) GLP-1 medicines caused microbiome changes and altered metabolism in mice (6) GLP-1 medicines tested in humans only had noticeable microbiome changes by 48 weeks (7) Despite not necessarily having slower gut motility, one study found that 88.9% of obese patients had SIBO (8) A meta analysis of people with IBS symptoms, found that up to 78% of people had SIBO, many of whom were undiagnosed (9) Overall, Sun and colleagues (1) could not prove a mechanistic link between GLP-1 medications and SIBO, however they did find that SIBO was twice as likely in GLP-1 users

11 In this trial, empagliflozin significantly reduced cardiovascular death by 38% (HR 0.62