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It acts locally within the gastrointestinal tract and is the appropriate choice when the clinical goal is gut-specific

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Larger doses make side effects, such as insomnia, more likely

Whilst GLP-1 receptor agonists can have modest blood pressure-lowering effects (generally beneficial for cardiovascular health), patients taking antihypertensive medications may experience excessive blood pressure reduction, leading to dizziness

Epub 2012 Mar 26

[4] For weight management, clinically meaningful weight loss is generally defined as 5% or more of initial body weight