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The theoretical synergy is that naltrexone can amplify satiety and potentially lower the effective dose of semaglutide needed
Other reported effects Beyond GI symptoms, clinical trials noted several other effects worth monitoring: Increased heart rate: A small, dose-dependent increase in resting heart rate was observed, consistent with what occurs with other GLP-1 agonists
Mu J, Woods J, Zhou YP, Roy RS, Li Z, Zycband E, et al
Antibody information is summarized in Supplemental Table 3
A typical course is 46 weeks, followed by reassessment
Based on the animal pharmacokinetic results, the intranasal dose can be further reduced from oral dose of 7- 14 mg daily to intranasal dose of 8-10 mg weekly or less, but systemic absorption and efficacy will be comparable or superior to oral tablets, with the faster control of blood glucose and body weight, and is free of GI toxicity, food effect and drug-drug interactions
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