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Common Adverse Effects of GLP-1s The most common adverse effects of GLP-1 receptor antagonists 26 are gastrointestinal-related, including: Nausea Diarrhea Vomiting Constipation Abdominal pain Dyspepsia/indigestion (upset stomach) Nausea is the most common of the GI symptoms, affecting up to 50% of users, but the frequency often gradually reduces as therapy continues