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showed that H5N1 triggers oxidative stress and ferroptosis through TRIM21-mediated regulation of the sequestosome 1 (SQSTM1/p62)-NRF2-KEAP1 axis, further facilitating viral replication (Wei et al., 2024)

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17 These ARE elements are closely associated with the genes for NQO1 and the GSTs (and many other genes) as discussed above, and when Nrf2 binds it induces the production of active proteins from these genes

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