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Strother says that when it comes to weight loss, most patients see steady progress over time and typically reach a plateau around 72 weeks (a little over a year)

Baseline assessment must include psychiatric stability (patient should be on a stable sertraline dose for at least 4 weeks), fasting glucose or HbA1c, renal function, and history of gastrointestinal disorders

doi: 10.1056/NEJM200012213432501

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The company's return policy states customers can return the unused portion for a full refund of the product cost