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The cancelled 2015 Phase I trial (NCT02637284) was almost certainly abandoned for this reason rather than buried by a regulator

(Kind of a big deal!) And if you have a deficiency, taking B12 pills or getting a B12 shot are both legit ways to up those B12 levels

Think of it like this, when you are starting a fire you need matches, wood, and paper

In such a study (16-week randomized, double-blind, placebo-controlled), 204 individuals with obesity but not diabetes were treated with self-administered subcutaneous injections of pramlintide (nonforced dose escalation 240 g) or placebo three times a day, 15 minutes before meals without concomitant lifestyle intervention (200)