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Blood pressure and pulse should be monitored regularly, particularly during dose titration of either medication

However, individual outcomes vary based on: Dose escalation Adherence Lifestyle modifications Baseline metabolic status Side Effects Profile Both medications share common GLP-1 class side effects: Nausea Vomiting Diarrhea Reduced appetite Zepbound may show slightly higher gastrointestinal intensity at higher doses due to dual receptor activity

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Many patients unconsciously increase portion sizes as appetite suppression eases, undoing the deficit that drove initial weight loss