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GIP is increasingly recognized as a "buffer" for metabolic health, enhancing insulin secretion in a glucose-dependent manner while potentially mitigating the nausea often associated with GLP-1 receptor activation

Wang G, Su Z, Li H, Xiao L, Li C, Lian G

Lilly, for instance, already markets tirzepatide and is also banking on orforglipron, a once-daily small-molecule GLP-1 agonist that can be taken as a pill

A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia

Treatment of adult obstructive sleep apnea with positive airway pressure: an American academy of sleep medicine systematic review, meta-analysis, and GRADE assessment

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