Notably, this heat stroke-induced LIRI differs fundamentally from reperfusion injury in hypovolemic shock or surgical contexts: in heat stroke, reperfusion is preceded by hyperthermia-induced endothelial damage and systemic inflammatory priming, which amplify oxidative stress (e.g., xanthine oxidase activation) and neutrophil infiltration
have dull, dry and tired skin, brittle hair and nails
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So while early animal data on BPC-157 is indeed fascinating, the lack of human trials means were still very much in the dark
Fowler N, Vo PT, Sisk CL, Klump KL