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GLP-1 projections to the PVH are increased in leptin-deficient mice To determine if leptin is required for normal development of GLP-1 projections to the hypothalamus, the density of GLP-1 immunoreactive inputs to the PVH was evaluated in leptin-deficient mice

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Experimental observations indicate stimulation of fibroblast proliferation, collagen production, and tissue remodeling responses following injury or stress