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In the SURPASS-2 study, the three doses of tirzepatide (5, 10, and 15 mg once weekly) were tested with the GLP-1RA semaglutide (1 mg once weekly) as a comparator in patients not optimally controlled on monotherapy with metformin (71)

The only remaining option was Xenical, a lipase inhibitor that prevents fat absorption but causes unpleasant gastrointestinal side effects

Its a hormone, like insulin, and like insulin, your body releases it into your bloodstream when you eat

This is a medical situation, not a dosing optimization problem

In other words, participants regained two-thirds of their prior weight loss after withdrawal of SC semaglutide 2.4mg weekly

Products like Pendulum GLP-1 Probiotic Pro are the first commercial applications of this science