Based on our transcriptomic data, all the primary hits of the CRISPR screen ( ABCC1 , SLC30A1 , and SLC39A14 ) are highly expressed in 1321N1 cells (data not shown)
Feldman 2014)
Mittal A., Phillips A
While glutathione primarily functions within cells, vitamin C operates in the extracellular space, allowing both to protect cellular integrity effectively
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Subsequently, the authors determined general radiosensitivity ( D 0 dose reducing surviving fraction to 37%), quasi-threshold doses ( D q ), and extrapolation numbers ( n ) from the survival curves and correlated these parameters with the cellular levels of GPx, catalase, CuZn superoxide dismutase (Cu/Zn-SOD), and Mn superoxide dismutase (Mn-SOD)