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D3 raises 25-OH D levels roughly 87% more effectively than an equivalent dose of D2, based on a meta-analysis by Tripkovic et al

The LEADER trial (liraglutide, N=9,340) and SUSTAIN-6 (semaglutide, N=3,297) did not show a statistically significant increase in pancreatitis versus placebo [13,14]

These observations suggest a significant contribution of CYPOR to NFT-induced Nrf2 activation in the HepG2 model, but also indicate that other cellular flavoprotein reductases are likely to be involved in the formation of the NFT radical anion and its subsequent activation of Nrf2 and synthesis of GCLC and glutathione