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Glyoxylate can be metabolized to oxalate by hydroxyacid oxidase 1 (encoded by the HAO1 gene

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Insulin/IGF-1 signaling also regulates the functions of the innate and adaptive immune systems

These features collectively establish COFs as a uniquely programmable platform for the integrated delivery of multimodal therapies, such as PDT, PTT, and CDT, together with immunomodulators, an advantage that remains challenging to achieve simultaneously with other existing nanocarriers