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Where PDA upregulates VEGFR2 and promotes angiogenesis, TB-500 increases actin polymerization and enhances cellular migration

Notably, the treatment demonstrated antiallodynic effects, meaning that it alleviated pain caused by stimuli that wouldnt normally induce pain in a non-inflamed subject

Pro-inflammatory adipokines (e.g., leptin, resistin) and adipose-derived exosomes (carrying miRNAs like miR-3074-5p) create a chronic inflammatory joint microenvironment by polarizing synovial macrophages toward an M1 phenotype and inhibiting anti-inflammatory adiponectin (1618)

It can also cause stomach cramps, vomiting, and allergies like redness

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