In summary, clarifying the link between the gut-joint axis and ferroptosis in OA would be of great significance not only for better understanding the pathological processes at multi-levels (local joint tissues, the gut environment, and circulation), but also from a unique angle for guiding novel therapies development in OA Deep investigative approach to understand how major gut bacterial metabolites (tryptophan-derived metabolites, TMAO and so on) modulate ferroptosis in OA is very promising to elucidate the central regulatory mechanism acted by the gut-joint axis on ferroptosis in OA
The company is currently planning trials in dogs and plans to release the implant commercially sometime in either 2028 or 2029
The long-term impact of maternal vitamin D status during pregnancy on offspring bone health remains unclear, especially in populations with high sun exposure yet persistent deficiency
PMID: 1979245
doi:10.1016/j.cellimm.2011.04.001, PMID: 21550026 Gosset P, Wallaert B, Tonnel AB, Fourneau C (1999) Thiol regulation of the production of TNF-, IL-6 and IL-8 by human alveolar macrophages
doi:10.1254/jphs.11r04fm
