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Key findings across the STEP trials: Average weight loss of ~15% of body weight roughly 15 kg (33 lbs) for a 100 kg (220 lb) person 87% of patients lost at least 5% of body weight, compared to 31% on placebo Nearly 70% of patients lost at least 10% of body weight About 1 in 3 patients lost 20% or more Weight loss was maintained throughout the treatment period with continued medication use Significant improvements in blood pressure, blood sugar, cholesterol, and inflammatory markers alongside weight loss These results are dramatically better than any prior weight loss medication

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ROS and RNS production in physiological conditions is maintained at low levels [25, 26] and used to regulate various physiological functions, including cell signaling, homeostasis, vascular tone, and immune reactions [27]

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Endogenous hydrogen peroxide up-regulates the expression of nitric oxide synthase in the kidney of SHR