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The patient underwent positron emission tomography (PET)/CT, which demonstrated high activity in the tumor and no metastatic disease

Results Genome-wide DNA methylation profiling identified over 5,000 differentially methylated CpG sites affecting genes involved in receptor tyrosine kinase signaling, phospho-metabolism, and immune pathways

Most patients experience the strongest appetite suppression (and nausea, stomach pain or vomiting) the first few days after an injection, with effects tapering slightly before the next scheduled dose

This breakthrough will undoubtedly pave the way for oral versions of other complex peptides currently only available as injectables

References Killion, E

Peer review Peer review information Nature Reviews Cancer thanks Dong Gao and the other, anonymous, reviewer(s) for their contribution to the peer review of this work