glp-1 and mood glp 1 changes Long-term Success of GLP-1s Hinges on More Than Just a Prescription What do the studies actually

But exendin-4 degrades in the body much slower than GLP-1

Across all studies, the safety profile was consistent with the broader GLP-1 class: nausea, diarrhea, and mild gastrointestinal symptoms were the most common side effects, typically occurring during the dose escalation phase

Lancet 396 , 819829 (2020)

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Am J Health Syst Pharm 62: 173181, 2005

These results suggest there is no excess cardiovascular risk with tirzepatide and are consistent with the improvements of numerous surrogate markers of cardiovascular health, including weight reduction, glycemic control with less hypoglycemia, blood pressure reduction, and improvements in the lipid profile