GLP-1s are separately approved for type 2 diabetes and chronic kidney disease, which are not the focus of this advisory
Human clinical trials are strong tools for detecting common side effects and gauging short-to-medium-term safety in the enrolled populations
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The ongoing TRIUMPH-Outcomes trial (NCT06383390) will provide definitive data on whether these benefits translate into a reduction in major adverse cardiovascular events (MACE)
The experts concurred that the differences in the action mechanisms may partially explain these results and could also help mitigate the undesirable cardiovascular physiological effects such as the increase of heart rate
Receptor binding and functional EC characterization in HEK293 cells expressing each of the three target receptors, including human and mouse orthologs
