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In some cases, patients have reported issues such as ruined skin , usually due to excessive application or improper formulation

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Alterations in the BCAA catabolic pathway result in neurologic dysfunction caused by the accumulation of BCAAs and their derivatives, branched-chain ketoacids (BCKA)

Similarly, patients with active malignancy warrant careful consideration given theoretical concerns about angiogenic effects potentially affecting tumor growth, though preclinical evidence suggests context-dependent effects that may inhibit rather than promote tumor angiogenesis

NMN is generally considered more effective due to its superior bioavailability and efficient conversion to NAD+ in cells

Simoni, R